Holly Springs was founded in 1836 on land the Chickasaw had held for centuries, and Rust College began there thirty years later. In 1866 the Reverend Moses Adams, a formerly enslaved minister, and Albert Collier McDonald, a white Methodist Episcopal clergyman, started a church school at Asbury Methodist Church for freed people. It was the first historically Black college founded in Mississippi.
It was chartered in 1870 as Shaw University, became Rust University in 1890 and took the name Rust College in 1914. Ida B. Wells attended in the 1870s, and her father, James Wells, served as a trustee. Perry Howard, a graduate of 1899, became an assistant U.S. attorney general under Warren G. Harding.
In the 1960s, under President Earnest A. Smith, the college supported voter registration, welcomed SNCC workers and let James Meredith spend weekends on campus while he was enrolled at Ole Miss. The college gained regional accreditation under William A. McMillan, who became president in 1967, and a new science building opened in 2008. It remains a small college supported by the United Methodist Church. The campus on Rust Avenue is a short walk from the Ida B. Wells-Barnett Museum.
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